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MMK7 inhibitor 4a
CAS No. ——
MMK7 inhibitor 4a( —— )
Catalog No. M16995 CAS No. ——
MMK7 inhibitor 4a is a potent, sepecific, covalent inhibitor of MMK7.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameMMK7 inhibitor 4a
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NoteResearch use only, not for human use.
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Brief DescriptionMMK7 inhibitor 4a is a potent, sepecific, covalent inhibitor of MMK7.
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DescriptionMMK7 inhibitor 4a is a potent, sepecific, covalent inhibitor of MMK7, displays >800-fold selectivity over EGFR-WT and EGFR-L858R/T790M; MMK7 inhibitor 4a formed a covalent bond to Cys218 at the end of the hinge region of MMK7; displayed an excellent selectivity profile at 1 uM against a panel of 320 kinases; potently inhibits cellular JNK at 1 uM and completely inhibited its downstream effector c-Jun with no effect on the JNK-pathway; MMK7 inhibitor 4a is a valuable probe for further investigation to elucidate the function of MKK7 in cellular studies and in vivo.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMAPK/ERK Signaling
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TargetMEK
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RecptorMEK
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight456.51
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Molecular FormulaC24H24N8O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(R)-1-(3-(5-(1-(4-acetylphenyl)-1H-1,2,3-triazol-4-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)piperidin-1-yl)prop-2-en-1-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wolle P, et al. J Med Chem. 2019 Feb 15. doi: 10.1021/acs.jmedchem.9b00102.
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